Lady Jessica was raised from birth by the Bene Gesserit, who intended to breed her to the House Atreides heir Leto Atreides I, to produce a daughter who would then breed with Feyd Rautha Harkonnen in order to produce the Kwisatz Hadarach, the one who would not only possess the genetic memories of all male and female ancestors, but also see into the future. Consequently, Jessica was provided with the most intense and advanced Bene Gesserit education and training.

The Bene Gesserit plan to couple Jessica with Duke Leto Atreides I initially appeared to work perfectly. Jessica became the official concubine of Leto Atreides I, which allowed him to also marry. Such political union prove advantageous for the Great House.

The relationship between the two quickly evolved into genuine love, and due this love, Jessica disobeyed her orders and give birth to a son, Paul Atreides, who would be heir of House Atreides, and ultimately ruined the Bene Gesserit plans.